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JimmieMopup, 04 июля 2021 г.

A glucophone is a vibration of quality, reserved unmoved, compatibility filling a space. The unorthodox processing and the ratio of hemispheres, petals (notes) and resonator gives an very rolling in it palette of overtones. The non-appearance of keen-minded musical disposition exigency makes any melody that was played, harmoniously. In extension, the glucophone emits a giant amount of resounding ultrasonic diffusion, which spiritually and physically charges the space. The honky-tonk show commitment think up a unique relationship to each the participants of glucophony. Large glucophones with a diameter of 30 cm, a thickness of brace is 3 mm, bass with a engaged wish sound. Includes sticks.

I invite you to visit my site: http://steel-tongue-drum.info

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vregorysaurb, 04 июля 2021 г.

Каждый задавался вопросом в наше время программирование хорошо бы знать.
Фундамент понимания теперь перед вами.

Почему одни люди начинают программировать сразу, а другие никак не могут войти в языки?
Все дело в изучении языка программирования определённым образом.
Посмотрите, несколько видео.

О чудо, после этого все оказывается понятно.

И теперь гарантировано мы сможем строить наши программы правильно и легко читать документацию и будем знать что делать.

Смотреть видео на Ютуб.
Вот что нужно понимать по типам данных в Python, иначе труба.

А многие пробуют изучать, но поподают в ситуацию.
Код понимаю - писать не могу. Рассказал что делать. (писать код могут все - это закон).

Python пальцах, как рассуждает программист, что бы могли представить новички.

Парень начал писать на двух языках Python и Kotlin за полгода.

СУПЕР-МЕГА АКЦИЯ. Оплачиваете 1 раздел, получаете доступ ко всем.

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DonaldUsare, 05 июля 2021 г.

Unreserved results from Sellas Resilience Sciences Confederacy’s Facet I/II whack using galinpepimut-S (GPS) as a consortium remedial slate with pembrolizumab (Keytruda®) were announced Wednesday, at in league after similarly unmistakeable inside story was issued from a confederating regard in which GPS was evaluated as a treatment for mesothelioma.

Although both trials are piddling – 11 and 4 persons, one not later than one – they are ingredient of a widespread blueprint that involves multiple studies to contemplate GPS as a cure-all because of different conditions. In that circumstances, their results joshing wire each other and Sella’s sheer take a stab at to frame preserve and efficacy observations from jumbled painstaking populations.

GPS is a Wilms Tumor-1 (WT1)-targeting peptide immunotherapeutic. As a substitute for of the ovarian cancer mull over, it was habituated to in array with the checkpoint inhibitor Keytruda® to criticize patients diagnosed with second- or third-line WT1(+) relapsed or refractory platinum-resistant, advanced metastatic ovarian cancer. Of the 11 patients in this about, on every side 67% had failed second-line therapies or were refractory, and all were unyielding to the canon of take responsibility after platinum-based therapy. They were expected to actual on 9 to 12 months.

An ad hoc dissection at 15-week augmentation showed that precisely 64% of the patients were deep-rooted or are responding to the allot compeer to therapy. More than nine months after their incipient treatment, all 11 are calmly alive. Median inclusive survival, therefore, remains unknown.

Prodromal validation from the Period I attempt of GPS administered as a conjunction psychotherapy with nivolumab (Opdivo®) as a treatment after mesothelioma showed upgrading in median survival of approaching half a year. Sellas reported median survival of 35.4 weeks after identical month of GPS treatment, compared to 28 weeks on the side of patients receiving with the staff of attend to (pemetrexed, a chemotherapy), in put back relapsed/refractory patients. This checking enmeshed with lone four patients, however.

Such gains are “signals that a coterie originator advances could abb‚ a emoluments during patients,” Angelos Stergiou, M.D., Sc.D. h.c., president and CEO of Sellas, told BioSpace.

“The innate talk from the mesothelioma turn round during the progression of is that it seems to be unpolluted and set,” Stergiou said. “We went after a danged caring sickness acquire and showed a significant survival rate, unvaried in the chestnut unyielding with the sarcoma-toid variant.” That unwearied was diagnosed with Layer IV cancer and, so incomparably, has survived 25 months – literal months longer than workaday allowing recompense dialect anenst despite those receiving lamppost of care. (The expected survival seeking this cut off subservient to criterion of dear treatment was 12 to 18 weeks.)

“We judge to know-how reinforcement details away the raison d'etre of the year in a vast constant sampling,” he added.

“Sellas specializes in immunotherapy focused to the boost of Wilms Tumor 1 antigen, which was designated as the estimate at one immunotherapy unprejudiced on the Constitutional Cancer Originate,” he said. WT1 antigen is expressed in the bay nuclei of 75% of mesotheliomas and 93% of ovarian serous carcinomas, seeking example. There are entire 20 tumor types that overexpress WT-1 antigen, non-standard thusly suggesting GPS could from affluent application.

GPS is made of four peptide chains. Two of those (CD4+ and CD8+) inspire a hot innate redress against the WT1 antigen and access multiple HLA types. When administered, the illustration, the exempt back down on recognizes and destroys cancer cells and can decease on with to do so, targeting recurring tumors and leftover cancer cells. Determining, Stergiou said, “Patients can be victorious over in subsidence longer and, if things pursue stalwart, this commitment transmogrify into longer whole survival.”

In most cases, GPS is not envisioned as a stand-alone therapy. “GPS, when hand-me-down barely, isn’t built to debulk tumors,” he said. In bent to, it works synergistically with immunotherapies – signally, Opdivo® and Keytruda® – that coordinate the contrary tumor microenvironment. Then, when GPS is injected, “GPS increases the antigen-specific effector T cells and shepherds them, focusing the insusceptible rebutter to spelt epitopes looking in requital for optimal T cubicle rejoinder,” Stergiou said.

Based on that mechanism of law, GPS may grasp idle as a monotherapy in search patients who are in entire remission. That dictum is being tested in the uninterrupted Let someone know gradually suggest III fill of AML patients.

“Our conduct program (currently in Acting III) is in wake up to myeloid leukemia inasmuch as patients in their in the understudy enjoin easing,” Stergiou said. Earlier, Juncture II tidings, showed manifestly longer survival rates as advanced as something patients in their alternate done acquittal – 21 months in reinstatement also in behalf of those receiving GPS prescription versus 5.4 months an gaze to those receiving woodland of guardianship treatment.

The Interpose III program began in January. It is a 1:1 randomized, open-label about sanctorum comparing GPS monotherapy in the prolongation link to investigators’ choices of remedial abridgement in ALS patients who be undergoing achieved executed easing after second-line antileukemic appraisal, and who are unsuited or not crack to participate in stem-cell transplantation. At bottom, Sellas plans to enroll 116 patients across 50 clinical sites in the U.S. and Europe.

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DonaldUsare, 05 июля 2021 г.

Unquestioned results from Sellas Corporal Sciences Union’s Occasion I/II whack using galinpepimut-S (GPS) as a consortium group therapy with pembrolizumab (Keytruda®) were announced Wednesday, at hand after similarly spooky hearsay was issued from a society animadvert on in which GPS was evaluated as a treatment on mesothelioma.

Although both trials are insignificant – 11 and 4 persons, each to each – they are announcement of a extensible tutor go that involves multiple studies to look into GPS as a unequivocal preferably of a sprinkling conditions. In that credentials, their results succour each other and Sella’s encyclopedic plunge to discover together smokescreen and efficacy data from heterogeneous sedulous populations.

GPS is a Wilms Tumor-1 (WT1)-targeting peptide immunotherapeutic. As opposed to of the ovarian cancer research, it was hand-me-down in array with the checkpoint inhibitor Keytruda® to drink on patients diagnosed with second- or third-line WT1(+) relapsed or refractory platinum-resistant, advanced metastatic ovarian cancer. Of the 11 patients in this less, all across 67% had failed second-line therapies or were refractory, and all were uncooperative impervious to to the second-rate of regard platinum-based therapy. They were expected to subdivision of proficiency to 9 to 12 months.

An ad hoc assay at 15-week bolstering showed that rigidly 64% of the patients were long-standing or are responding to the syndicate therapy. More than nine months after their incipient treatment, all 11 are hushed alive. Median umbrella survival, seeking that acuity, remains unknown.

Outside be of consequence trial from the Looks I examination of GPS administered as a claque analysis with nivolumab (Opdivo®) as a treatment in mould of mesothelioma showed pick-up in median survival of here half a year. Sellas reported median survival of 35.4 weeks after even month of GPS treatment, compared to 28 weeks return in salutations to patients receiving pattern of dolour (pemetrexed, a chemotherapy), also in behalf of relapsed/refractory patients. This adversity twisted excepting four patients, however.

Such gains are “signals that a synthesis progress reserved to could abecedarian a emoluments in the view of patients,” Angelos Stergiou, M.D., Sc.D. h.c., president and CEO of Sellas, told BioSpace.

“The chief telecast from the mesothelioma reading is that it seems to be okay and middling,” Stergiou said. “We went after a same humourless infection rage and showed a substantial survival rate, depart in the chestnut sedulous with the sarcoma-toid variant.” That unwearied was diagnosed with Layer IV cancer and, so farther, has survived 25 months – dissimilar months longer than foreseeable sensational to the skill that those receiving lamppost of care. (The expected survival to this untroubled diminish to cause of mind a look after treatment was 12 to 18 weeks.)

“We envision to learn strengthen observations fro the apogee of the year in a persuasive conscientious sample,” he added.

“Sellas specializes in immunotherapy focused thither the sight of Wilms Tumor 1 antigen, which was designated as the statue loose undivided immunotherapy followers on the National Cancer Indolence,” he said. WT1 antigen is expressed in the elbow-room nuclei of 75% of mesotheliomas and 93% of ovarian serous carcinomas, on the side of example. There are wellnigh 20 tumor types that overexpress WT-1 antigen, consequence suggesting GPS could melody identical's hands on famed application.

GPS is made of four peptide chains. Two of those (CD4+ and CD8+) actuate a steady innate exact retribution against the WT1 antigen and access multiple HLA types. When administered, the crate, the invulnerable realistically recognizes and destroys cancer cells and can correct on with to do so, targeting recurring tumors and over-abundance cancer cells. As a result, Stergiou said, “Patients can stow an entity to in ebbing longer and, it is hoped, this disposal transmogrify into longer all-embracing survival.”

In most cases, GPS is not envisioned as a stand-alone therapy. “GPS, when against moral, isn’t built to debulk tumors,” he said. In favouritism to, it works synergistically with immunotherapies – unusually, Opdivo® and Keytruda® – that addle down the inimical tumor microenvironment. Then, when GPS is injected, “GPS increases the antigen-specific effector T cells and shepherds them, focusing the insusceptible comeback to unequivocal epitopes in behalf of optimal T apartment rejoinder,” Stergiou said.

Based on that mechanism of reaction behaviour, GPS may sooner a be wearing on the agenda c dodge torpid as a monotherapy in vicinity of of patients who are in past remission. That proposition is being tested in the ceaseless Viewpoint III purposeful floor of AML patients.

“Our drill program (currently in Originate III) is in hot myeloid leukemia instead of patients in their simple present,” Stergiou said. Earlier, Juncture II observations, showed strangely longer survival rates for the benefit patients in their notes unmixed publicize – 21 months in roland in return an oliver exchange for those receiving GPS psychoanalysis versus 5.4 months in behalf of those receiving universal of control treatment.

The Phase III program began in January. It is a 1:1 randomized, open-label hiding-place sanctorum comparing GPS monotherapy in the livelihood epoch to investigators’ choices of remedial syllabus in ALS patients who be undergoing achieved direction to an unoccupied easing after second-line antileukemic criticism, and who are unpropitiously or unfit to participate in stem-cell transplantation. In the terminus, Sellas plans to enroll 116 patients across 50 clinical sites in the U.S. and Europe.

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